Sensor design on inexpensive substrates for biochemical applications release_k3owwhtrhnfhvkjw2cymyueexm

by Miaosi Li

Published by Monash University.

2017  

Abstract

This research project focuses on exploring new sensor design methods on inexpensive substrates for various biomedical and chemical applications, in order to improve the health and life quality of people living in less-industrialized countries and remote regions. People living in these areas are more susceptible to diseases due to shortage of funds, medical facilities, medical knowledge and professional staff. This project has noticed that for most existing point-of-care diagnostics designed for developing areas, although are affordable, sensitive, specific and rapid ("ASSR"), cannot be practically utilized in these areas, for they are not easily operated by non-professional and untrained personnel. In particular, a desirable user-oriented device is required to be user-friendly, equipment-free and delivered to end-users ("UED"), and achieving these demands, therefore, is the aim of this project. This thesis includes two parts, presenting two original sensor design concepts respectively. One is the "sample-only" method, which only requires the user to introduce the sample to the sensor with no extra effort during the assay; the other one is the "text-reporting" method, which can report the assay result directly with unambiguous text messages to the user. Both of the two concepts effectively address the "UED" problems in existing devices. The sensors developed by the new design concepts were conducted through fabrication on inexpensive substrates, which are cellulose paper and plastic (or glass) slides throughout this research. The patterning of these substrates is processed through traditional industrialized surface treatment, paper-sizing and printing techniques, making the devices affordable and easily-obtained. The feasibility of these two concepts is then demonstrated through applying them to practical applications. The first application is blood typing. The "sample-only" method allows the user to get clear blood typing results by only introducing one blood drop during the assay. The "text-reporting" method des [...]
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