Microglia form satellites with different neuronal subtypes in the adult murine central nervous system release_k3nbtqvkprfanjwtqmctvg6tre

by Olga Bakina, Helmut Kettenmann, Christiane Nolte

Published in Journal of Neuroscience Research by Wiley.

2022  

Abstract

Microglia are the innate immune cells of the central nervous system (CNS). In the adult uncompromised CNS, they have a highly ramified morphology and continuously extend and retract their processes. A subpopulation of microglial cells forms close soma-to-soma contacts with neurons and have been termed satellite microglia, yet the role of such interaction is largely unknown. Here, we analyzed the distribution of satellite microglia in different areas of the CNS of adult male mice applying transgenic- and immunolabeling of neuronal subtypes and microglia followed by three-dimensional imaging analysis. We quantified satellite microglia associated with GABAergic and glutamatergic neurons in the somatosensory cortex, striatum, and thalamus; with dopaminergic and serotonergic neurons in the basal forebrain and raphe nucleus, respectively; and with cerebellar Purkinje cell neurons. Satellite microglia in the retina were assessed qualitatively. Microglia form satellites with all neuronal subtypes studied, whereas a preference for a specific neuron subtype was not found. The occurrence and frequency of satellite microglia is determined by the histo-architectural organization of the brain area and the densities of neuronal somata therein.
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Type  article-journal
Stage   published
Date   2022-02-25
Language   en ?
DOI  10.1002/jnr.25026
PubMed  35213755
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ISSN-L:  0360-4012
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