Neurogenic plasma extravasation in response to mechanical, chemical and thermal stimuli release_jgxqgqqps5dmzbyjhl6xfxe7gm

by P V Andrews, R D Helme

Published in Clinical and experimental neurology .

Volume 23p95-100 (1987)


Nociceptors at distal terminals of unmyelinated primary afferent nerve fibres mediate neurogenic inflammation. Most studies have examined only the neurogenic inflammatory response to non-physiological antidromic electrical nerve stimulation. It has not been possible to determine whether polymodal nociceptors mediate the response to physiological stimulation with mechanical, chemical and thermal stimuli. In this study we have induced plasma protein extravasation to stimulation with wool fabric (81 +/- 9 micrograms/mL), bradykinin (86 +/- 8 micrograms/mL) and heat (111 +/- 16 micrograms/mL) in perfused vacuum-induced blisters on the rat hind footpad. These values represent significant increases over the protein concentration of 30 micrograms/mL (p less than 0.005; p less than 0.001; p less than 0.001, respectively; n = 6 to 8 for each group). Plasma extravasation was significantly reduced for each stimulus modality (p less than 0.001; p less than 0.05; p less than 0.01, respectively) in animals pretreated as neonates with capsaicin, demonstrating that part of the response is neurogenically mediated. It is concluded that neurogenic inflammation to polymodal physiological stimuli occurs in the rat through capsaicin-sensitive primary afferent nerve fibres.
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Type  article-journal
Stage   published
Year   1987
Language   en ?
PubMed  2444370
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ISSN-L:  0196-6383
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