Optically Pumped Magnetoencephalography in Epilepsy
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Umesh Vivekananda, Stephanie Mellor, Tim M Tierney, Niall Holmes, Elena Boto, James Leggett, Gillian Roberts, Ryan Hill, Vladimir Litvak, Matthew J. Brookes, Richard Bowtell, Gareth R Barnes (+1 others)
2019
Abstract
<jats:title>Abstract</jats:title>Our aim was to demonstrate the first use of Optically Pumped Magnetoencephalography (OP-MEG) in an epilepsy patient with unrestricted head movement. Current clinical MEG uses a traditional SQUID system for recording MEG signal, where sensors are cryogenically cooled and housed in a helmet in which the patient's head is fixed. Here we use a different type of sensor (OPM), which operates at room temperature and can be placed directly on the patient's scalp, permitting free head movement. We performed two 30 minute OP-MEG recording sessions in a patient with refractory focal epilepsy and compared these with clinical scalp EEG performed earlier. OP-MEG was able to identify analogous interictal activity to scalp EEG, and source localise this activity to an appropriate brain region. This is the first application of OP-MEG in human epilepsy. Future directions include simultaneous EEG/OP-MEG recording and prolonged OP-MEG telemetry.
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Date 2019-12-14
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