One-two punch injury to tolerance mechanisms in graft-versus-host disease release_i2skntfmhfd2dkmuj5ykkignie

by Léolène J. Carrington, Ivan Maillard

Published in Journal of Clinical Investigation by American Society for Clinical Investigation.

2020   Volume 130, Issue 4, p1625-1628

Abstract

Chronic graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation that resembles autoimmunity, with unclear pathogenesis and few effective therapeutic options. In this issue of the JCI, Dertschnig et al. used mouse models to investigate the basis of T cell autoreactivity following GVHD. Notably, GVHD caused irreversible damage to a population of tolerogenic stromal cells that display peripheral tissue-restricted antigens in lymph nodes, which impaired their capacity to purge and suppress autoreactive T cells. Together with damage to central tolerance mechanisms in the thymus, these findings outline a critical one-two punch injury that profoundly disrupts immune tolerance in this devastating disease.
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Type  article-journal
Stage   published
Date   2020-03-09
Language   en ?
DOI  10.1172/jci136139
PubMed  32149731
PMC  PMC7108886
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