Immunogenetic markers for ulcerative colitis in adult population of moscow region release_hqve3qtctvcltdqul7rmpbgzbm

by D S Stavtsev, T A Astrelina, M M Azova, O A Mayorova, V J Zinkin, L L Lebedeva, T V Pukhlikova, A A Chumak, O V Knyazev

Published in RUDN Journal of Medicine by Peoples' Friendship University of Russia (RUDN University).

2014   p53-59

Abstract

The article presents the results of the study of the genetic polymorphism of HLA-antigens in 65 adult patients with ulcerative colitis (UC) living in Moscow region. It was found that certain groups of HLA alleles are associated with the pathogenesis of UC. Immunogenetic factors of predisposition and sustainability to this disease depending on gender and age were revealed. The relationship of immunogenetic factors with clinical forms of the disease, course of the UC and response to therapy with glucocorticoids were shown.
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