Reducing variation in hospital mortality for alcohol-related liver disease in North West England release_hngnb4rqhrd65ldc3zl6pzxplm

by Constantinos Kallis, Pete Dixon, Benjamin Silberberg, Lynn Affarah, Mustafa Shawihdi, Ruth Grainger, Nancy Prospero, Mike Pearson, Anthony Marson, Subramanian Ramakrishnan, Paul Richardson, Steve Hood (+1 others)

Published in Alimentary Pharmacology and Therapeutics by Wiley.

2020  

Abstract

Variations in emergency care quality for alcohol-related liver disease (ARLD) have been highlighted. To determine whether introduction of a regional quality improvement (QI) programme was associated with a reduction in potentially avoidable inpatient mortality. Retrospective observational cohort study using hospital administrative data spanning a 1-year period before (2014/2015) and 3 years after a QI initiative at seven acute hospitals in North West England. The intervention included serial audit of a bundle of process metrics. An algorithm was developed to identify index ("first") emergency admissions for ARLD (n = 3887). We created a standardised mortality ratio (SMR) to compare relative mortality and regression models to examine risk-adjusted odds of death. In 2014/2015, three of seven hospitals had an SMR above the upper control limit ("outliers"). Adjusted odds of death for patients admitted to outlier hospitals was higher than non-outliers (OR 2.13, 95% CI 1.32-3.44, P = 0.002). Following the QI programme there was a step-wise reduction in outliers (none in 2017/2018). Odds of death was 67% lower in 2017/2018 compared to 2014/2015 at original outlier hospitals, but unchanged at other hospitals. Process audit performance of outliers was worse than non-outliers at baseline, but improved after intervention. There was a reduction in unexplained variation in hospital mortality following the QI intervention. This challenges the pessimism that is prevalent for achieving better outcomes for patients with ARLD. Notwithstanding the limitations of an uncontrolled observational study, these data provide hope that co-ordinated efforts to drive adoption of evidence-based practice can save lives.
In text/plain format

Archived Content

There are no accessible files associated with this release. You could check other releases for this work for an accessible version.

"Dark" Preservation Only
Save Paper Now!

Know of a fulltext copy of on the public web? Submit a URL and we will archive it

Type  article-journal
Stage   published
Date   2020-05-22
Language   en ?
DOI  10.1111/apt.15781
PubMed  32441393
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  0269-2813
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 299b9bd4-4f63-4315-af4c-a7579115489d
API URL: JSON