The Use of Bioinformatics for Studying HIV Evolutionary and Epidemiological History in South America release_hlom7oz2e5bere4wyz6v452ify

by Gonzalo Bello, Marcelo A. Soares, Carlos G. Schrago

Published in AIDS Research and Treatment by Hindawi Limited.

2011   Volume 2011, p1-13

Abstract

The South American human immunodeficiency virus type 1 (HIV-1) epidemic is driven by several subtypes (B, C, and F1) and circulating and unique recombinant forms derived from those subtypes. Those variants are heterogeneously distributed around the continent in a country-specific manner. Despite some inconsistencies mainly derived from sampling biases and analytical constrains, most of studies carried out in the area agreed in pointing out specificities in the evolutionary dynamics of the circulating HIV-1 lineages. In this paper, we covered the theoretical basis, and the application of bioinformatics methods to reconstruct the HIV spatial-temporal dynamics, unveiling relevant information to understand the origin, geographical dissemination and the current molecular scenario of the HIV epidemic in the continent, particularly in the countries of Southern Cone.
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Type  article-journal
Stage   published
Year   2011
Language   en ?
DOI  10.1155/2011/154945
PubMed  22162803
PMC  PMC3226295
Wikidata  Q35579280
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