The previously published method (Thrombosis Res. 3, 665, 1973) was used for the estimation of endothelaemia. The method is based on an ennumeration of endothelial cells after a differential centrifugation and removal of platelets by an addition of adenosine-diphosphate. The normal values in humans are from 4-5 cells in one microlitre of plasma. Significant increases were found in patients with acute myocardial infarction and in patients with severe angina pectoris. The increase attains maximum values on the first days of myocardial infarction and within 3-5 days they return gradually to original values. A series of clinical as well as animal experiments was carried out to elucidate this phenomenon.
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