Molecular Epidemiology of Foot-and-Mouth Disease Virus in the Context of Transboundary Animal Movement in the Far North Region of Cameroon release_hgh4emmudnbuhlihotufce7xzi

by Miranda R. Bertram, Carla Bravo de Rueda, Rebecca Garabed, Simon Dickmu Jumbo, Mark Moritz, Steven Pauszek, Souley Abdoulkadiri, Luis L. Rodriguez, Jonathan Arzt

Published in Frontiers in Veterinary Science by Frontiers Media SA.

2018   Volume 5, p320

Abstract

Transboundary movement of animals is an important mechanism for foot-and-mouth disease virus (FMDV) spread in endemic regions, such as Cameroon. Several transboundary animal trade routes cross the Far North Region of Cameroon, and cattle moved on foot along these routes often come in contact with native (sedentary and transhumant) herds. The purpose of this study was to investigate the role of transboundary trade cattle in the epidemiology of FMDV in the Far North Region of Cameroon. A total of 582 oropharyngeal fluid (OPF) samples were collected from asymptomatic transboundary trade cattle at official border check points and 57 vesicle epithelial tissues were collected from clinically affected native cattle in the Far North Region of Cameroon during 2010-2014. Viral protein 1 (VP1) coding sequences were obtained from 6 OPF samples from transboundary cattle (4 serotype O, 2 serotype SAT2) and 19 epithelial tissue samples from native cattle (7 serotype O, 3 serotype SAT2, 9 serotype A). FMDV serotype O viruses belonged to two topotypes (East Africa-3 and West Africa), and phylogenetic analyses suggested a pattern of continuous transmission in the region. Serotype SAT2 viruses belonged to a single topotype (VII), and phylogenetic analysis suggested a pattern of repeated introductions of different SAT2 lineages in the region. Serotype A viruses belonged to topotype AFRICA/G-IV, and the pattern of transmission was unclear. Spearman rank correlation analysis of VP1 coding sequences obtained in this study from transboundary and native cattle showed a positive correlation between genetic distance and time for serotype O (ρ = 0.71, p = 0.003) and between genetic distance and geographic distance for serotype SAT2 (ρ = 0.54, p = 0.1). These data suggest that transboundary trade cattle participate in the transmission of FMDV in the Far North Region of Cameroon, however the dynamics and direction of transmission could not be determined in this study. Results of this study contribute to the understanding of transboundary FMDV epidemiology in Central Africa and will help to inform control programs in Cameroon and in the region.
In text/plain format

Archived Files and Locations

application/pdf  3.1 MB
file_pc2xxhblurbrxnzttbbwsbjwhm
pdfs.semanticscholar.org (aggregator)
web.archive.org (webarchive)

Web Captures

https://www.frontiersin.org/articles/10.3389/fvets.2018.00320/full
2020-08-31 15:07:15 | 40 resources
webcapture_f4istswzvnbwzfig4d3hty2rde
web.archive.org (webarchive)
Read Archived PDF
Archived
Type  article-journal
Stage   published
Date   2018-12-14
Language   en ?
Container Metadata
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registery
ISSN-L:  2297-1769
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 38999f4c-3c8d-488c-b204-4e509c84bc0b
API URL: JSON