The effect of aging on T-regulatory cell frequency in HIV infection release_gswkcwppfngtjl7fprwykkiw6e

by Allan R. Tenorio, John Spritzler, Jeffrey Martinson, Caroline N. Gichinga, Richard B. Pollard, Michael M. Lederman, Robert C. Kalayjian, Alan L. Landay

Published in Clinical Immunology by Elsevier BV.

2009   Volume 130, Issue 3, p298-303


T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV(+) subjects had a total T-reg percent that is 2.8% (p=0.02) higher than among younger HIV(+), older HIV(-) and younger HIV(-) subjects. In HIV(+) subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r=-0.45, p=0.002) and Candida (r=-0.43, p=0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV(+) subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV(+) population and may play a role in the accelerated disease progression seen in older HIV-infected persons.
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Type  article-journal
Stage   published
Date   2008-11-12
Language   en ?
DOI  10.1016/j.clim.2008.10.001
PubMed  19008157
PMC  PMC2662473
Wikidata  Q37143202
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ISSN-L:  1521-6616
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