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Bioengineered Microphysiological Placental Models: Towards Improving Understanding of Pregnancy Health and Disease release_gkckybvzojc7zk33psqpctkdeu

by Marnie Winter, Tanja Jankovic-Karasoulos, Claire T Roberts, Tina Bianco-Miotto, Benjamin Thierry

Entity Metadata (schema)

abstracts[] {'sha1': '2d4deb95d552d11111f2c7f1e7dfff6d5a29a7dd', 'content': 'Driven by a lack of appropriate human placenta models, recent years have seen the introduction of bioengineered in vitro models to better understand placental health and disease. Thus far, the focus has been on the maternal-foetal barrier. However, there are many other physiologically and pathologically significant aspects of the placenta that would benefit from state-of-the-art bioengineered models, in particular, integrating advanced culture systems with contemporary biological concepts such as organoids. This critical review defines and discusses the key parameters required for the development of physiologically relevant in vitro models of the placenta. Specifically, it highlights the importance of cell type, mechanical forces, and culture microenvironment towards the use of physiologically relevant models to improve the understanding of human placental function and dysfunction.', 'mimetype': 'text/plain', 'lang': 'en'}
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contribs[] {'index': 0, 'creator_id': None, 'creator': None, 'raw_name': 'Marnie Winter', 'given_name': 'Marnie', 'surname': 'Winter', 'role': 'author', 'raw_affiliation': 'ARC Centre of Excellence in Convergent BioNano Science and Technology and Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, South Australia, 5095, Australia. Electronic address: marnie.winter@mymail.unisa.edu.au.', 'extra': {}}
{'index': 1, 'creator_id': None, 'creator': None, 'raw_name': 'Tanja Jankovic-Karasoulos', 'given_name': 'Tanja', 'surname': 'Jankovic-Karasoulos', 'role': 'author', 'raw_affiliation': 'Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia, 5042, Australia.', 'extra': {}}
{'index': 2, 'creator_id': None, 'creator': None, 'raw_name': 'Claire T Roberts', 'given_name': 'Claire T', 'surname': 'Roberts', 'role': 'author', 'raw_affiliation': 'Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia, 5042, Australia.', 'extra': {}}
{'index': 3, 'creator_id': None, 'creator': None, 'raw_name': 'Tina Bianco-Miotto', 'given_name': 'Tina', 'surname': 'Bianco-Miotto', 'role': 'author', 'raw_affiliation': 'School of Agriculture, Food, and Wine, University of Adelaide, Adelaide, South Australia, 5005, Australia; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, 5005, Australia; Waite Research Institute, University of Adelaide, Adelaide, South Australia, 5005, Australia.', 'extra': {}}
{'index': 4, 'creator_id': None, 'creator': None, 'raw_name': 'Benjamin Thierry', 'given_name': 'Benjamin', 'surname': 'Thierry', 'role': 'author', 'raw_affiliation': 'ARC Centre of Excellence in Convergent BioNano Science and Technology and Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, South Australia, 5095, Australia.', 'extra': {}}
ext_ids {'doi': '10.1016/j.tibtech.2021.03.009', 'wikidata_qid': None, 'isbn13': None, 'pmid': '33965246', 'pmcid': None, 'core': None, 'arxiv': None, 'jstor': None, 'ark': None, 'mag': None, 'doaj': None, 'dblp': None, 'oai': None, 'hdl': None}
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language en
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release_date 2021-05-05
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release_type article-journal
release_year 2021
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title Bioengineered Microphysiological Placental Models: Towards Improving Understanding of Pregnancy Health and Disease
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work_id 6lqfgvhlpbhofh32iwf7xw5hse
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pubmed.pub_types ['Journal Article']