Sympathetic vasoconstriction in skeletal muscle: Modulatory effects of aging, exercise training, and sex release_ghuosez7tnhurjwt42dakfidjq

by Darren S DeLorey

Published in Applied Physiology, Nutrition and Metabolism by Canadian Science Publishing.

2021   p1-11

Abstract

The sympathetic nervous system (SNS) is a critically important regulator of the cardiovascular system. The SNS controls cardiac output and its distribution, as well as peripheral vascular resistance and blood pressure at rest and during exercise. Aging is associated with increased blood pressure and decreased skeletal muscle blood flow at rest and in response to exercise. The mechanisms responsible for the blunted skeletal muscle blood flow response to dynamic exercise with aging have not been fully elucidated; however, increased muscle sympathetic nerve activity (MSNA), elevated vascular resistance and a decline in endothelium-dependent vasodilation are commonly reported in older adults. In contrast to aging, exercise training has been shown to reduce blood pressure and enhance skeletal muscle vascular function. Exercise training has been shown to enhance nitric oxide-dependent vascular function and may improve the vasodilatory capacity of the skeletal muscle vasculature; however, surprisingly little is known about the effect of exercise training on the neural control of circulation. The control of blood pressure and skeletal muscle blood flow also differs between males and females. Blood pressure and MSNA appear to be lower in young females compared to males. However, females experience a larger increase in MSNA with aging compared to males. The mechanism(s) for the altered SNS control of vascular function in females remain to be determined.
 Novelty:
 • This review will summarize our current understanding of the effects of aging, exercise training and sex on sympathetic vasoconstriction at rest and during exercise. 
 • Areas where additional research is needed are also identified. 
In application/xml+jats format

Archived Files and Locations

application/pdf  254.8 kB
file_imjw3lr5rfhzfjxoysowyugely
cdnsciencepub.com (web)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2021-08-04
Language   en ?
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  1715-5312
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 903fe5c1-0c4f-4c5b-af79-b71fad223183
API URL: JSON