Serologic study by competitive enzyme-linked immunosorbent assay of pregnancy-associated alpha 2-glycoprotein in hepatitis B virus infection release_gcx5jdkauvgvrcirui5ic3vzj4

by J A Zarzur, M Aldao, S Sileoni, H Guglielmone, M A Vides

Published in Diagnostic immunology.

1986   Volume 4, Issue 6, p277-80


Serum levels of pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG) in patients with hepatitis B virus (HBV) infection were compared with those of healthy male subjects used as controls by a competitive enzyme-linked immunosorbent assay (ELISA). Assay parameters were optimized, and minimal detectable concentration was 100 ng/ml. The alpha 2-PAG levels in 22/26 acute HBV patients showed a very significant statistical difference when compared with controls (x2 = 19.93, p less than 0.0005). On the other hand, 8/8 chronic persistent HBV patients showed high levels with a range between 51 to 200 ug/ml (x2 = 18.16, p less than 0.0005). There was no significant difference between asymptomatic HBsAg carriers and controls. Although alpha 2-PAG apparently exhibits immunosuppressive properties similar to other factors present in HBV infection, follow-up studies are needed to elucidate its role in the natural evolution of this disease.
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Type  article-journal
Stage   published
Year   1986
Language   en ?
PubMed  3816048
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ISSN-L:  0735-3111
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