Day care setting ideal place for vaccination. Pediatrics (HAV) release_ftvca6lytrbv7hcbrt7v3lzpuq

by S Boyles

Published in Vaccine weekly.

1996   p14-5


Hepatitis A is highly endemic in developing countries. For example, in Sao Paulo, Brazil, 100% and 40.3% of lower and middle socioeconomic level children aged 2-11 years, respectively, have antibodies to hepatitis A. 90.4% of voluntary middle class adult blood donors are infected with the virus. Day care centers represent an important source of hepatitis A in several communities. Richtmann et al. investigated the immunogenicity and safety of the hepatitis A virus (HAV) strain GBM vaccine among 40 children attending a day care center in Sao Paulo. The children received three times 0.5 and 1.0 ml of the vaccine, the second and third dose one and six months after the first dose, respectively. All of the subjects had protective levels of antibodies in serum after two inoculations, with no serious adverse reactions observed. During the 8th month of follow-up, an outbreak of hepatitis A occurred in the day care center. Nine of the 27 control subjects developed either high titers of IgM class anti-HAV or acute hepatitis, but none of the vaccinated subjects developed signs or symptoms of hepatitis. This killed HAV vaccine was therefore found to be safe and effective in this area of high prevalence hepatitis A infection. Vaccination clearly benefits children in high-risk areas and should also be considered in areas of lower risk where day care centers are nonetheless important in facilitating the spread of HAV.
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Type  article-journal
Stage   published
Date   1996-04-22
Language   en ?
PubMed  12290904
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ISSN-L:  1074-2921
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Revision: 7db23b49-637e-46a2-8099-500b66240d40