{"DOI":"10.6084/m9.figshare.4714618.v129","abstract":"Prokaryotic\n\"blood group A/B-like\" antigenic structures basically induce cross-reactive anti-A/B immunoglobulins, which due to clonal\nselection neither arise in blood group A nor in B individuals but occur\nexclusively in blood group O. While bacterial endotoxins non-specifically\nstimulate the formation of all immunoglobulins, involving the\nanti-A/B isoagglutinins, a definite, adaptive immunological induction of these\nagglutinins appears to be restricted to blood group O(H) individuals. In the\nnon-O blood groups, anti-A/B reactivity is exerted by a primarily blood\ngroup-independent, polyreactive and thymus-independent non-immune IgM molecule\nthat has undergone the phenotype-specific, glycosidic accommodation of plasma\nproteins, which reduces or excludes anti-self reactivity, however, necessarily\ninvolves impairment of immunity. While blood group A phenotype development thus\nis associated with impaired formation of adaptive and innate immunoglobulins,\nit promotes susceptibility to malaria infection via its intrinsic enzyme\nfunctions, initiating a self-destructive glycosidic, phenotypic accommodation\nof a \"wrong eukaryote\". Blood group A phenotype-specific\nGalNAc transferase activities, expressed by both cell surfaces and plasma\nproteins, and serine/threonine kinases from Plasmodium\nfalciparum, which over the parasite's life cycle get into the red blood cell (RBC) of the human host, might provide the metabolic condition\nfor adhesion protein and RBC rosette formation, assumingly based on heterologous O-glycosylation,\nbreaking a species barrier and completing the\n\"serine repeat antigen\". Thus, the lack of blood group A phenotype-specific GalNAc glycosylation(s) most likely explains the obvious protection of human blood group O(H) individuals from severe\nmalaria infection, and suggests a new molecular definition of the immunological (therapeutic) target. In\nfact, the human histo (blood) group O finally represents the worldwide most\ncommon blood type, associated with a superior, complex immunity, [...]","author":[{"family":"Arend","given":"Peter"}],"id":"unknown","issued":{"date-parts":[[2017,6,10]]},"publisher":"Figshare","title":"Central immunological position of the human histo (blood) group O(H).","type":"article-journal"}