@misc{medina-puche_tan_dogra_wu_rosas-diaz_wang_ding_zhang_fu_kim_et al._2019, 
  title={A novel pathway linking plasma membrane and chloroplasts is co-opted by pathogens to suppress salicylic acid-dependent defences}, 
  DOI={10.1101/837955}, 
  abstractNote={<jats:p>Chloroplasts are crucial players in the activation of defensive hormonal responses during plant-pathogen interactions. Here, we show that a plant virus-encoded protein re-localizes from the plasma membrane to chloroplasts upon triggering plant defence, interfering with the chloroplast-dependent activation of anti-viral salicylic acid (SA) biosynthesis. Strikingly, we have found that plant pathogens from different kingdoms seem to have convergently evolved to target chloroplasts and impair SA-dependent defences following an association with membranes, which is based on the co-existence of two subcellular targeting signals, an N-myristoylation site and a chloroplast transit peptide. This pattern is also present in plant proteins, at least one of which conversely activates SA defences from the chloroplast. Taken together, our results suggest that a pathway linking plasma membrane to chloroplasts and activating defence exists in plants, and that such pathway has been co-opted by plant pathogens during host-pathogen co-evolution to promote virulence through suppression of SA responses.</jats:p>}, 
  publisher={Cold Spring Harbor Laboratory}, 
  author={Medina-Puche, Laura and Tan, Huang and Dogra, Vivek and Wu, Mengshi and Rosas-Diaz, Tabata and Wang, Liping and Ding, Xue and Zhang, Dan and Fu, Xing and Kim, Chanhong and et al.}, 
  year={2019}, 
  month={Nov}
  }