Cervical intraepithelial neoplasia and the risk of spontaneous preterm birth: A Dutch population-based cohort study with 45,259 pregnancy outcomes release_edcqsc3ep5hvhhgrsds6aqbcwu

by Diede Loopik, Joris van Drongelen, Ruud Bekkers, Quirinus J. M. Voorham, Willem Melchers, Leon F. A. G. Massuger, Folkert J. van Kemenade, Albert Siebers

Published in PLoS Medicine by Public Library of Science (PLoS).

Volume 18, Issue 6 e1003665 (2021)

Abstract

<jats:sec id="sec001"> <jats:title>Background</jats:title> Excisional procedures of cervical intraepithelial neoplasia (CIN) may increase the risk of preterm birth. It is unknown whether this increased risk is due to the excision procedure itself, to the underlying CIN, or to secondary risk factors that are associated with both preterm birth and CIN. The aim of this study is to assess the risk of spontaneous preterm birth in women with treated and untreated CIN and examine possible associations by making a distinction between the excised volume of cervical tissue and having cervical disease. </jats:sec> <jats:sec id="sec002"> <jats:title>Methods and findings</jats:title> This Dutch population-based observational cohort study identified women aged 29 to 41 years with CIN between 2005 and 2015 from the Dutch pathology registry (PALGA) and frequency matched them with a control group without any cervical abnormality based on age at and year of pathology outcome (i.e., CIN or normal cytology) and urbanization (&lt;100,000 inhabitants or ≥100,000 inhabitants). All their 45,259 subsequent singleton pregnancies with a gestational age ≥16 weeks between 2010 and 2017 were identified from the Dutch perinatal database (Perined). Nineteen potential confounders for preterm birth were identified. Adjusted odds ratios (ORs) were calculated for preterm birth comparing the 3 different groups of women: (1) women without CIN diagnosis; (2) women with untreated CIN; and (3) women with treated CIN prior to each childbirth. In total, 29,907, 5,940, and 9,412 pregnancies were included in the control, untreated CIN, and treated CIN group, respectively. The control group showed a 4.8% (1,002/20,969) proportion of spontaneous preterm birth, which increased to 6.9% (271/3,940) in the untreated CIN group, 9.5% (600/6,315) in the treated CIN group, and 15.6% (50/321) in the group with multiple treatments. Women with untreated CIN had a 1.38 times greater odds of preterm birth compared to women without CIN (95% confidence interval (CI) 1.19 to 1.60; <jats:italic>P</jats:italic> &lt; 0.001). For women with treated CIN, these odds 2.07 times increased compared to the control group (95% CI 1.85 to 2.33; <jats:italic>P</jats:italic> &lt; 0.001). Treated women had a 1.51 times increased odds of preterm birth compared to women with untreated CIN (95% CI 1.29 to 1.76; <jats:italic>P</jats:italic> &lt; 0.001). Independent from cervical disease, a volume excised from the cervix of 0.5 to 0.9 cc increased the odds of preterm birth 2.20 times (37/379 versus 1,002/20,969; 95% CI 1.52 to 3.20; <jats:italic>P</jats:italic> &lt; 0.001). These odds further increased 3.13 times and 5.93 times for women with an excised volume of 4 to 8.9 cc (90/724 versus 1,002/20,969; 95% CI 2.44 to 4.01; <jats:italic>P</jats:italic> &lt; 0.001) and ≥9 cc (30/139 versus 1,002/20,969; 95% CI 3.86 to 9.13; <jats:italic>P</jats:italic> &lt; 0.001), respectively. Limitations of the study include the retrospective nature, lack of sufficient information to calculate odds of preterm birth &lt;24 weeks, and that the excised volume could only be calculated for a select group of women. </jats:sec> <jats:sec id="sec003"> <jats:title>Conclusions</jats:title> In this study, we observed a strong correlation between preterm birth and a volume of ≥0.5 cc excised cervical tissue, regardless of the severity of CIN. Caution should be taken when performing excisional treatment in women of reproductive age as well as prudence in case of multiple biopsies. Fertile women with a history of performing multiple biopsies or excisional treatment for CIN may benefit from close surveillance during pregnancy. </jats:sec>
In application/xml+jats format

Archived Files and Locations

application/pdf  1.9 MB
file_cm6g6cqtbreclarnltadi7h6zi
web.archive.org (webarchive)
storage.googleapis.com (publisher)
Read Archived PDF
Archived
Type  article-journal
Stage   published
Date   2021-06-04
Language   en ?
Journal Metadata
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registery
ISSN-L:  1549-1277
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 5264c4f8-d34d-4048-989f-d873da50eb7f
API URL: JSON