abstracts[] |
{'sha1': '7a62be74f9a8583303cb3b8c769139ae0c6804d7', 'content': '<jats:title>Abstract</jats:title>\n <jats:bold>Background</jats:bold>Domestic yaks play an indispensable role in sustaining the livelihood of Tibetans and other ethnic groups on the Qinghai-Tibetan Plateau (QTP), by providing milk and meat. They have evolved numerous physiological adaptations to high-altitude environment, including strong blood oxygen transportation capabilities and high metabolism. The roles of DNA methylation and gene expression in milk production and high-altitudes adaptation need further exploration. <jats:bold>Results </jats:bold>We performed genome-wide DNA methylome and transcriptome analyses of breast, lung, and biceps brachii muscle tissues from yaks of different ages. We identified 432,350 differentially methylated regions (DMRs) across the age groups within each tissue. The post-mature breast tissue had considerably more differentially methylated regions (155,957) than that from the three younger age groups. Hypomethylated genes with high expression levels might regulate milk production by influencing protein processing in the endoplasmic reticulum. According to weighted gene correlation network analysis, the "hub" gene ZGPAT was highly expressed in the post-mature breast tissue, indicating that it potentially regulates the transcription of 280 genes that influence protein synthesis, processing, and secretion. The tissue network analysis indicated that high expression of HIF1A regulates energy metabolism in the lung. <jats:bold>Conclusions</jats:bold>This study provides a basis for understanding the epigenetic mechanisms underlying milk production in yaks, and the results offer insight to breeding programs aimed at improving milk production.', 'mimetype': 'application/xml+jats', 'lang': None}
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contribs[] |
{'index': 0, 'creator_id': None, 'creator': None, 'raw_name': 'Jinwei Xin', 'given_name': 'Jinwei', 'surname': 'Xin', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': {'seq': 'first'}}
{'index': 1, 'creator_id': None, 'creator': None, 'raw_name': 'Zhixin Chai', 'given_name': 'Zhixin', 'surname': 'Chai', 'role': 'author', 'raw_affiliation': 'Southwest Minzu University', 'extra': None}
{'index': 2, 'creator_id': None, 'creator': None, 'raw_name': 'Chengfu Zhang', 'given_name': 'Chengfu', 'surname': 'Zhang', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
{'index': 3, 'creator_id': None, 'creator': None, 'raw_name': 'Qiang Zhang', 'given_name': 'Qiang', 'surname': 'Zhang', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
{'index': 4, 'creator_id': None, 'creator': None, 'raw_name': 'Yong Zhu', 'given_name': 'Yong', 'surname': 'Zhu', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
{'index': 5, 'creator_id': None, 'creator': None, 'raw_name': 'Hanwen Cao', 'given_name': 'Hanwen', 'surname': 'Cao', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
{'index': 6, 'creator_id': None, 'creator': None, 'raw_name': 'Yangji Cidan', 'given_name': 'Yangji', 'surname': 'Cidan', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
{'index': 7, 'creator_id': None, 'creator': None, 'raw_name': 'Xiaoying Chen', 'given_name': 'Xiaoying', 'surname': 'Chen', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
{'index': 8, 'creator_id': None, 'creator': None, 'raw_name': 'Hui Jiang', 'given_name': 'Hui', 'surname': 'Jiang', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
{'index': 9, 'creator_id': None, 'creator': None, 'raw_name': 'Jincheng Zhong', 'given_name': 'Jincheng', 'surname': 'Zhong', 'role': 'author', 'raw_affiliation': 'Southwest minzu university', 'extra': None}
{'index': 10, 'creator_id': None, 'creator': None, 'raw_name': 'Qiumei Ji', 'given_name': 'Qiumei', 'surname': 'Ji', 'role': 'author', 'raw_affiliation': 'State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement', 'extra': None}
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files[] |
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