[b0]
via grobid
|
Investigation of 4-piperidinols as novel H3 antagonists
James T. Anderson, Michael Campbell, Jianmin Wang, Kurt R. Brunden, John J. Harrington, Alain Stricker-Krongrad, Jianping Song, Chris Doucette (+ more) 2010
Bioorganic & Medicinal Chemistry Letters
doi:10.1016/j.bmcl.2010.08.099
pmid:20833043
|
|
[B2]
via crossref
|
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
Ash Bahl, Patrick Barton, Keith Bowers, Steven Brough, Richard Evans, Christopher A. Luckhurst, Tobias Mochel, Matthew W.D. Perry (+ more) 2012
Bioorganic & Medicinal Chemistry Letters
doi:10.1016/j.bmcl.2012.08.124
pmid:23031591
|
|
[B3]
via crossref
|
Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system
Nadine Becker, Sonja Stoelzle, Sven Göpel, David Guinot, Patrick Mumm, Claudia Haarmann, Daniela Malan, Heribert Bohlen (+ more) 2013
Journal of pharmacological and toxicological methods
doi:10.1016/j.vascn.2013.03.009
pmid:23567076
|
web.archive.org [PDF]
|
[B4]
via crossref
|
Synthesis and evaluation of 4-alkoxy-[1′-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4′-piperidine)] analogues as histamine-3 receptor antagonists
Nadine C. Becknell, Reddeppa Reddy Dandu, Jacquelyn A. Lyons, Lisa D. Aimone, Rita Raddatz, Robert L. Hudkins 2012
Bioorganic & Medicinal Chemistry Letters
doi:10.1016/j.bmcl.2011.11.038
pmid:22153342
|
|
[B5]
via crossref
|
Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death
M.L. De Bruin, M. Pettersson, R.H.B. Meyboom, A.W. Hoes, H.G.M. Leufkens 2005
European Heart Journal
doi:10.1093/eurheartj/ehi092
pmid:15637086
|
web.archive.org [PDF]
|
[B6]
via crossref
|
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
Mark E Curran, Igor Splawski, Katherine W Timothy, G.Michael Vincen, Eric D Green, Mark T Keating 1995
Cell
doi:10.1016/0092-8674(95)90358-5
pmid:7889573
|
web.archive.org [PDF]
|
[B7]
via crossref
|
Using Electrophysiology and In Silico Three-Dimensional Modeling to Reduce Human Ether-à-go-go Related Gene K+ Channel Inhibition in a Histamine H3 Receptor Antagonist Program
Adam J. Davenport, Clemens Möller, Alexander Heifetz, Michael P. Mazanetz, Richard J. Law, Andreas Ebneth, Mark J. Gemkow 2010
Assay and drug development technologies
doi:10.1089/adt.2010.0322
pmid:21133680
|
|
[B8]
via crossref
|
Utility of frozen cell lines in medium throughput electrophysiology screening of hERG and NaV1.5 blockade
Brian T. Donovan, Tania Bakshi, Sarah E. Galbraith, Christopher J. Nixon, Lisa A. Payne, Stan F. Martens 2011
Journal of pharmacological and toxicological methods
doi:10.1016/j.vascn.2011.09.002
pmid:21996251
|
|
[B9]
via crossref
|
High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
John Dunlop, Mark Bowlby, Ravikumar Peri, Dmytro Vasilyev, Robert Arias 2008
Nature reviews. Drug discovery
doi:10.1038/nrd2552
pmid:18356919
|
|
[B10]
via crossref
|
Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology.
Farre
2009
Comb. Chem. High Throughput Screen.
volume:12
doi:10.2174/138620709787047966
|
|
[b10]
via grobid
|
Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology
Niels Fertig, Andrea Bruggemann, Mohamed Kreir, Michael George, Sonja Stoelzle, Claudia Haarmann, Cecilia Farre, Alison Haythornthwaite 2009
Combinatorial chemistry & high throughput screening
doi:10.2174/138620709787047966
pmid:19149489
|
web.archive.org [PDF]
|
[B12]
via crossref
|
Population Patch Clamp Improves Data Consistency and Success Rates in the Measurement of Ionic Currents
A. Finkel 2006
Journal of Biomolecular Screening
doi:10.1177/1087057106288050
pmid:16760372
|
|
[b12]
via grobid
|
Finkel, A., Wittel, A., Yang, N., Handran, S., Hughes, J., and Costantin, J. (2006). Population patch clamp improves data consistency and success rates in the measurement of ionic currents. J. Biomol. Screen. 11, 488-496. doi: 10.1177/1087057106288050
|
|
[b13]
via grobid
|
Development of a high-throughput electrophysiological assay for the human ether-à-go-go related potassium channel hERG
Daniel J. Gillie, Steven J. Novick, Brian T. Donovan, Lisa A. Payne, Claire Townsend 2013
Journal of pharmacological and toxicological methods
doi:10.1016/j.vascn.2012.10.002
pmid:23103595
|
|
[b14]
via grobid
|
The 'overly-sensitive' heart: sodium channel block and QRS interval prolongation
Gary A Gintant, David J Gallacher, Michael K Pugsley 2011
British Journal of Pharmacology
doi:10.1111/j.1476-5381.2011.01433.x
pmcid:PMC3174406
pmid:21488862
|
web.archive.org [PDF]
|
[b15]
via grobid
|
Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine
Gary A. Gintant, Brian F. Hoffman 1984
Pflügers Archiv: European Journal of Physiology
doi:10.1007/bf00585029
pmid:6326044
|
|
[b16]
via grobid
|
IonFlux: A Microfluidic Patch Clamp System Evaluated with Human Ether-à-go-go Related Gene Channel Physiology and Pharmacology
Andrew P. Golden, Nianzhen Li, Qin Chen, Tony Lee, Tanner Nevill, Xueying Cao, Juliette Johnson, Gül Erdemli (+ more) 2011
Assay and drug development technologies
doi:10.1089/adt.2010.0362
pmid:21561375
|
web.archive.org [PDF]
|
[B18]
via crossref
|
Safety pharmacology — Current and emerging concepts
Junnat Hamdam, Swaminathan Sethu, Trevor Smith, Ana Alfirevic, Mohammad Alhaidari, Jeffrey Atkinson, Mimieveshiofuo Ayala, Helen Box (+ more) 2013
Toxicology and Applied Pharmacology
doi:10.1016/j.taap.2013.04.039
pmid:23732082
|
web.archive.org [PDF]
|
[B19]
via crossref
|
Characterizing Human Ion Channels in Induced Pluripotent Stem Cell–Derived Neurons
Alison Haythornthwaite, Sonja Stoelzle, Alexander Hasler, Andrea Kiss, Johannes Mosbacher, Michael George, Andrea Brüggemann, Niels Fertig 2012
Journal of Biomolecular Screening
doi:10.1177/1087057112457821
pmid:22923790
|
|
[B20]
via crossref
|
4-Phenoxypiperidine pyridazin-3-one histamine H3 receptor inverse agonists demonstrating potent and robust wake promoting activity
Robert L. Hudkins, Allison L. Zulli, Reddeppa reddy Dandu, Ming Tao, Kurt A. Josef, Lisa D. Aimone, R. Curtis Haltiwanger, Zeqi Huang (+ more) 2012
Bioorganic & Medicinal Chemistry Letters
doi:10.1016/j.bmcl.2012.01.026
pmid:22290075
|
|
[B21]
via crossref
|
Histamine H3-Receptor Inverse Agonists as Novel Antipsychotics
Chihiro Ito 2009
Central Nervous System Agents in Medicinal Chemistry
doi:10.2174/187152409788452036
pmid:20021346
|
|
[b21]
via grobid
|
Ito, C. (2009). Histamine H3-receptor inverse agonists as novel antipsychotics. Cent. Nerv. Syst. Agents Med. Chem. 9, 132-136. doi: 10.2174/187152409788452036
|
|
[b22]
via grobid
|
Automated Patch Clamping Using the QPatch
[chapter]
Kenneth A. Jones, Nicoletta Garbati, Hong Zhang, Charles H. Large 2009
Msphere
doi:10.1007/978-1-60327-258-2_10
pmid:19551364
|
|
[B24]
via crossref
|
Novel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity.
Levoin
2011
Bioorg. Med. Chem. Lett.
volume:21
doi:10.1016/j.bmcl.2011.07.006
|
|
[b24]
via grobid
|
Novel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity
Nicolas Levoin, Olivier Labeeuw, Thierry Calmels, Olivia Poupardin-Olivier, Isabelle Berrebi-Bertrand, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Marc Capet 2011
Bioorganic & Medicinal Chemistry Letters
doi:10.1016/j.bmcl.2011.07.006
pmid:21802950
|
|
[b25]
via grobid
|
Robotic multiwell planar patch-clamp for native and primary mammalian cells
Carol J Milligan, Jing Li, Piruthivi Sukumar, Yasser Majeed, Mark L Dallas, Anne English, Paul Emery, Karen E Porter (+ more) 2009
Nature Protocols
doi:10.1038/nprot.2008.230
pmcid:PMC2645065
pmid:19197268
|
web.archive.org [PDF]
|
[B27]
via crossref
|
Predictive QSAR models development and validation for human ether-a-go-go related gene (hERG) blockers using newer tools.
Moorthy
2014
J. Enzyme Inhib. Med. Chem.
volume:29
doi:10.3109/14756366.2013.779264
|
|
[B28]
via crossref
|
Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656
Sang-Joon Park, Ki-Suk Kim, Eun-Joo Kim 2008
Journal of Applied Toxicology
doi:10.1002/jat.1252
pmid:17516459
|
|
[B29]
via crossref
|
Toward a new gold standard for early safety: automated temperature-controlled hERG test on the patchliner.
Polonchuk
2012
Front. Pharmacol.
volume:3
doi:10.3389/fphar.2012.00003
|
|
[B30]
via crossref
|
Multiple Mechanisms in the Long-QT Syndrome: Current Knowledge, Gaps, and Future Directions
D. M. Roden, R. Lazzara, M. Rosen, P. J. Schwartz, J. Towbin, G. M. Vincent 1996
Circulation
doi:10.1161/01.cir.94.8.1996
pmid:8873679
|
|