Biorecognizable Nanoparticles Based On Hyaluronic Acid/Poly(Ε-Caprolactone) Block Copolymer release_c7me74d2ivanxmpz6eq2t2wryi

by Jong Ho Hwang, Dae Hwan Kang, Young-IL Jeong

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abstracts [{'sha1': '04fee11402119e0f1258627cfcdd3df29df7624a', 'content': 'Since hyaluronic acid (HA) receptor such as CD44 is<br>\nover-expressed at sites of cancer cells, HA can be used as a targeting<br>\nvehicles for anti-cancer drugs. The aim of this study is to synthesize<br>\nblock copolymer composed of hyaluronic acid and<br>\npoly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for<br>\nanticancer drug targeting against CD44 receptor of tumor cells.<br>\nChemical composition of HAPCL was confirmed using 1H NMR<br>\nspectroscopy. Doxorubicin (DOX) was incorporated into polymeric<br>\nmicelles of HAPCL. The diameters of HAPHS polymeric micelles<br>\nwere changed around 80nm and have spherical shapes. Targeting<br>\npotential was investigated using CD44-overexpressing. When<br>\nDOX-incorporated polymeric micelles was added to KB cells, they<br>\nrevealed strong red fluorescence color while blocking of CD44<br>\nreceptor by pretreatment of free HA resulted in reduced intensity,<br>\nindicating that HAPCL polymeric micelles have targetability against<br>\nCD44 receptor.', 'mimetype': 'text/plain', 'lang': 'en'}]
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contribs [{'index': 0, 'creator_id': None, 'creator': None, 'raw_name': 'Jong Ho Hwang', 'given_name': 'Jong Ho', 'surname': 'Hwang', 'role': 'author', 'raw_affiliation': None, 'extra': None}, {'index': 1, 'creator_id': None, 'creator': None, 'raw_name': 'Dae Hwan Kang', 'given_name': 'Dae Hwan', 'surname': 'Kang', 'role': 'author', 'raw_affiliation': None, 'extra': None}, {'index': 2, 'creator_id': None, 'creator': None, 'raw_name': 'Young-IL Jeong', 'given_name': None, 'surname': None, 'role': 'author', 'raw_affiliation': None, 'extra': None}]
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ext_ids {'doi': '10.5281/zenodo.1087285', 'wikidata_qid': None, 'isbn13': None, 'pmid': None, 'pmcid': None, 'core': None, 'arxiv': None, 'jstor': None, 'ark': None, 'mag': None, 'doaj': None, 'dblp': None, 'oai': None, 'hdl': None}
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language en
license_slug CC-BY
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publisher Zenodo
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release_date 2013-07-26
release_stage published
release_type article-journal
release_year 2013
revision 897191a7-e411-46c3-bd50-30e5c6441166
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title Biorecognizable Nanoparticles Based On Hyaluronic Acid/Poly(Ε-Caprolactone) Block Copolymer
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datacite.license [{'rights': 'Creative Commons Attribution 4.0', 'rightsUri': 'https://creativecommons.org/licenses/by/4.0'}, {'rights': 'Open Access', 'rightsUri': 'info:eu-repo/semantics/openAccess'}]
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datacite.relations [{'relatedIdentifier': '10.5281/zenodo.1087284', 'relatedIdentifierType': 'DOI', 'relationType': 'IsVersionOf'}]
datacite.resourceType Journal article
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datacite.subjects [{'subject': 'Hyaluronic acid'}, {'subject': 'CD44 receptor'}, {'subject': 'biorecognizable\nnanoparticles'}, {'subject': 'block copolymer.'}]
release_month 7