Biorecognizable Nanoparticles Based On Hyaluronic Acid/Poly(Ε-Caprolactone) Block Copolymer release_c7me74d2ivanxmpz6eq2t2wryi

by Jong Ho Hwang, Dae Hwan Kang, Young-IL Jeong

Published by Zenodo.

2013  

Abstract

Since hyaluronic acid (HA) receptor such as CD44 is<br> over-expressed at sites of cancer cells, HA can be used as a targeting<br> vehicles for anti-cancer drugs. The aim of this study is to synthesize<br> block copolymer composed of hyaluronic acid and<br> poly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for<br> anticancer drug targeting against CD44 receptor of tumor cells.<br> Chemical composition of HAPCL was confirmed using 1H NMR<br> spectroscopy. Doxorubicin (DOX) was incorporated into polymeric<br> micelles of HAPCL. The diameters of HAPHS polymeric micelles<br> were changed around 80nm and have spherical shapes. Targeting<br> potential was investigated using CD44-overexpressing. When<br> DOX-incorporated polymeric micelles was added to KB cells, they<br> revealed strong red fluorescence color while blocking of CD44<br> receptor by pretreatment of free HA resulted in reduced intensity,<br> indicating that HAPCL polymeric micelles have targetability against<br> CD44 receptor.
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Type  article-journal
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Date   2013-07-26
Language   en ?
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