Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis release_bsxt4r6vyvhapm2qgb47ntp3vy

by Caroline A. Crowther, Philippa F. Middleton, Merryn Voysey, Lisa Askie, Sasha Zhang, Tanya K. Martlow, Fariba Aghajafari, Elizabeth V. Asztalos, Peter Brocklehurst, Sourabh Dutta, Thomas J. Garite, Debra A. Guinn (+11 others)


In this study, we found that repeat prenatal corticosteroids given to women at ongoing risk of preterm birth after an initial course reduced the likelihood of their infant needing respiratory support after birth and led to neonatal benefits. Body size measures at birth were lower in infants exposed to repeat prenatal corticosteroids. Our findings suggest that to provide clinical benefit with the least effect on growth, the number of repeat treatment courses should be limited to a maximum of three and the total dose to between 24 mg and 48 mg.
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Published in PLoS Medicine by Public Library of Science (PLoS)
ISSN-L 1549-1277
Volume 16
Issue 4
Page(s) e1002771
Release Date 2019-04-12
Container Type journal
Publisher Public Library of Science (PLoS)
Primary Language en (lookup)

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Date   2019-04-12
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