Uric Acid Levels in Normotensive Children of Hypertensive Parents release_bpuusciy7zemndrwdygb3ahufe

by Ali Yildirim, Fatma Keles, Pelin Kosger, Gokmen Ozdemir, Birsen Ucar, Zubeyir Kilic

Published in International Journal of Chronic Diseases by Hindawi Limited.

Volume 2015p1-6 (2015)

Abstract

This study evaluated uric acid concentrations in normotensive children of parents with hypertension. Eighty normotensive children from families with and without a history of essential hypertension were included. Concentrations of lipid parameters and uric acid were compared. Demographic and anthropometric characteristics were similar in the groups. Systolic and diastolic blood pressure were higher in the normotensive children of parents with hypertension without statistically significant difference (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo>&gt;</mml:mo><mml:mn fontstyle="italic">0.05</mml:mn></mml:math>). Uric acid concentrations were higher in the normotensive children of parents with hypertension (4.61 versus 3.57 mg/dL,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0.01</mml:mn></mml:math>). Total cholesterol and triglyceride concentrations were similar in the two groups. Systolic and diastolic blood pressure were significantly higher in control children aged &gt;10 years (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0.01</mml:mn></mml:math>). Uric acid levels were significantly higher in all children with more pronounced difference after age 10 of years (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0.001</mml:mn></mml:math>). Positive correlations were found between the level of serum uric acid and age, body weight, body mass index, and systolic and diastolic blood pressure in the normotensive children of parents. The higher uric acid levels in the normotensive children of hypertensive parents suggest that uric acid may be a predeterminant of hypertension. Monitoring of uric acid levels in these children may allow for prevention or earlier treatment of future hypertension.
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Type  article-journal
Stage   published
Year   2015
Language   en ?
DOI  10.1155/2015/747082
PubMed  26464873
PMC  PMC4590931
Wikidata  Q36112601
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ISSN-L:  2314-5749
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