@article{büchel_schäfer_1970,
title={2-Anilinothiophene als Entkoppler der oxydativen Phosphorylierung in Mitochondrien / 2-Anilinothiophenes, Uncouplers of Oxidative Phosphorylation in Mitochondria},
volume={25},
DOI={10.1515/znb-1970-1232},
abstractNote={A series of NH-acidic 2-anilino-3,5-dinitro-thiophenes (II), 2-anilino-3,4-dinitro-5-halo-thiophenes (VI), and some 3,5-dinitro-thienole-derivatives (IX, X) were synthesized. Compounds II and VI are potent uncouplers of oxidative phosphorylation in rat liver mitochondria. The most active comcounds yielded a 50% uncoupling at a concentration of 10-7 ᴍ.
With some of the 2-anilino-3,5-dinitro-5-halo-thiophenes (BDCT or DDCT), added to respiring liver mitochondria, a transitory uncoupling of energy-linked reactions could be observed which is comparable to the phosphorylating cycles produced by ADP. The mechanism of this effect is discussed},
number={12},
publisher={Walter de Gruyter GmbH},
author={Büchel and Schäfer},
year={1970},
month={Dec}
}