Introduction. Various forms of rhinosinusitis affect up to 15 of the adult population and 5 of childrens population in the world. The cause of acute rhinosinusitis is a variety of viruses and bacteria. Purpose. The study the antimicrobial effect of Apicold Propo, nasal spray on clinical isolates of microorganisms that are the most common causative agents of acute bacterial sinusitis in Ukraine. Materials and methods. There was studied the effect of Apicold Propo, nasal spray (producer APIFARMA d.o.o.) on clinical isolates of the microorganisms Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, Pseudomonas aeruginosa (2 strains of wild type and hospital type) and Candida albicans isolated from nose of sick patients. Antimicrobial activity was evaluated in 5, 10 and 20 minutes of exposure. Bactericidal and fungicidal action (inhibition of the growth of microorganism cells on Petri dishes) is expressed as a percentage in accordance with the control. Results and discussion. Apicold Propo, nasal spray has 100 antimicrobial effect on the clinical isolate of Moraxella catarrhalis in 5 minutes, 100 antimicrobial effect on the clinical isolate of Streptococcus pneumonia in 20 minutes, 99 antimicrobial effect on the clinical isolate of Haemophilus influenza in 20 minutes, 48.7 fungicidal effect on Candida albicans strain in 20 minutes. Apicold Propo nasal spray has 65.7 antimicrobial effect on the clinical isolate Pseudomonas aeruginosa (wild type) in 20 minutes. There is no antimicrobial effect of Apicold Propo, nasal spray on the hospital strain Pseudomonas aeruginosa, which has resistance to the majority of antibiotics. Conclusions. Apicold Propo, nasal spray has antimicrobial effect on clinical isolates of Moraxella catarrhalis, Streptococcus pneumonia (100), Haemophilus influenza (99), clinical isolate Pseudomonas aeruginosa of wild type (65,7), fungicidal effect on Candida albicans strain (48,7). There is no antimicrobial effect on the hospital strain of Pseudomonas aerugi [...]
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