Wound infection monitoring is a matter of high interest in wound treatment. Therefore, we extracted sensor parameters suitable to identify massive pathogen presence. One method is to measure neutrophil-derived extracellular DNA as an immediate response of the immune system. We proofed that impedance measurement is a reasonable measurement technique for this parameter. Our sensor concept comprises a plenary or fiber-based setup which could be integrated into a wound cover. Proof-of-principle experiments using impedance spectroscopy in cell cultures showed a dependency between extracellular DNA formation and impedance rise. This was verified by microscopic observation of fluorescently stained samples. A reproducible impedance signal deviation of in average 34% after lately 4 hours was observed.
Archived Files and Locations
|application/pdf 1.3 MB ||
access all versions, variants, and formats of this works (eg, pre-prints)