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D9.2 - Impedance Measurement of Wound Infection Status
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by
A. Schröter, G. Gerlach, A. Rösen-Wolff, AMA Association For Sensor Technology E.V., Sophie-Charlotten-Str. 15, 14059 Berlin, Germany
Published
by AMA Service GmbH, P.O. Box 2352, 31506 Wunstorf, Germany.
2013
Abstract
Wound infection monitoring is a matter of high interest in wound treatment. Therefore, we extracted sensor parameters suitable to identify massive pathogen presence. One method is to measure neutrophil-derived extracellular DNA as an immediate response of the immune system. We proofed that impedance measurement is a reasonable measurement technique for this parameter. Our sensor concept comprises a plenary or fiber-based setup which could be integrated into a wound cover. Proof-of-principle experiments using impedance spectroscopy in cell cultures showed a dependency between extracellular DNA formation and impedance rise. This was verified by microscopic observation of fluorescently stained samples. A reproducible impedance signal deviation of in average 34% after lately 4 hours was observed.
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