Microstructural MRI Correlates of Cognitive Impairment in Multiple Sclerosis: The Role of Deep Gray Matter release_77z2xuwn2rc6vjrl5jkm7yi3ny

by Marco Pitteri, Ilaria Boscolo Galazzo, Lorenza Brusini, Federica Cruciani, Caterina Dapor, Damiano Marastoni, Gloria Menegaz, Massimiliano Calabrese

Published in Diagnostics by MDPI AG.

2021   Volume 11, p1103

Abstract

Although cognitive impairment (CI) is frequently observed in people with multiple sclerosis (pwMS), its pathogenesis is still controversial. Conflicting results emerged concerning the role of microstructural gray matter (GM) damage especially when involving the deep GM structures. In this study, we aimed at evaluating whether differences in cortical and deep GM structures between apparently cognitively normal (ACN) and CI pwMS (36 subjects in total) are present, using an extensive set of diffusion MRI (dMRI) indices and conventional morphometry measures. The results revealed increased anisotropy and restriction over several deep GM structures in CI compared with ACN pwMS, while no changes in volume were present in the same areas. Conversely, reduced anisotropy/restriction values were detected in cortical regions, mostly the pericalcarine cortex and precuneus, combined with reduced thickness of the superior frontal gyrus and insula. Most of the dMRI metrics but none of the morphometric indices correlated with the Symbol Digit Modality Test. These results suggest that deep GM microstructural damage can be a strong anatomical substrate of CI in pwMS and might allow identifying pwMS at higher risk of developing CI.
In application/xml+jats format

Archived Files and Locations

application/pdf  1.7 MB
file_iacn4yof6jc4zch4gyhb2vkwmy
res.mdpi.com (publisher)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2021-06-16
Language   en ?
Container Metadata
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registry
ISSN-L:  2075-4418
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 75ff489f-3c4c-4428-b981-c7a1e71d8042
API URL: JSON