Endogenous reward mechanisms and their importance in stress reduction, exercise and the brain release_6vqlx6sp2ze3tbhgytncbcy7e4

by Tobias Esch, George B. Stefano

Published in Archives of Medical Science by Termedia Sp. z.o.o..

2010   Volume 6, Issue 3, p447-455


Stress can facilitate disease processes and causes strain on the health care budgets. It is responsible or involved in many human ailments of our time, such as cardiovascular illnesses, particularly related to the psychosocial stressors of daily life, including work. Besides pharmacological or clinical medical treatment options, behavioral stress reduction is much-needed. These latter approaches rely on an endogenous healing potential via life-style modification. Hence, research has suggested different ways and approaches to self-treat stress or buffer against stressors and their impacts. These self-care-centred approaches are sometimes referred to as mind-body medicine or multi-factorial stress management strategies. They consist of various cognitive behavioral techniques, as well as relaxation exercises and nutritional counselling. However, a critical and consistent element of modern effective stress reduction strategies are exercise practices. With regard to underlying neurobiological mechanisms of stress relief, reward and motivation circuitries that are imbedded in the limbic regions of the brain are responsible for the autoregulatory and endogenous processing of stress. Exercise techniques clearly have an impact upon these systems. Thereby, physical activities have a potential to increase mood, i.e., decrease psychological distress by pleasure induction. For doing so, neurobiological signalling molecules such as endogenous morphine and coupled nitric oxide pathways get activated and finely tuned. Evolutionarily, the various activities and autoregulatory pathways are linked together, which can also be demonstrated by the fact that dopamine is endogenously converted into morphine which itself leads to enhanced nitric oxide release by activation of constitutive nitric oxide synthase enzymes. These molecules and mechanisms are clearly stress-reducing.
In text/plain format

Archived Files and Locations

application/pdf  81.7 kB
www.termedia.pl:80 (web)
web.archive.org (webarchive)
www.termedia.pl (web)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2010-06-30
Language   en ?
DOI  10.5114/aoms.2010.14269
PubMed  22371784
PMC  PMC3282525
Wikidata  Q35765846
Container Metadata
Open Access Publication
Not in Keepers Registry
ISSN-L:  1734-1922
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: c82d49d6-181d-4235-ac5f-2a5bc0149ed4