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Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
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by
Antonia Cianciulli, Liam Coulthard, Owen Hawksworth, John Lee, Xiang X. Li, Vincenzo Mitolo, Peter Monk, Maria A. Panaro, Trent Woodruff
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in IUPHAR/BPS Guide to Pharmacology CITE by Edinburgh University Library.
2020 Volume 2020
Abstract
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3aR and C5aR), causing cell activation and triggering cellular degranulation that contributes to the local inflammation.
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