Background: The sequence of induction of anesthesia, laryngoscopy hemodynamic changes and autonomic reflex activity which may be a cause of concern in many high risk patients. It is a sympathetic reflex associated with increase plasma norepinephrine concentration and is premedication. These changes may lead to a number of complication which include myocardial ischemia/infarction, cardiac failure, intracranial haemorrhage and increase in intracranial pressure. intravenous Esmolol and Labetolol for attenuating cardiovascular response following larngoscopy and intubation have been compared and evaluated in normotensive surgical patients. laryngoscopy and intubation in Esmolol treated group compared to Labetalol treated group. 2. To study rise in SBP, DBP & MAP while laryngoscopy and intubation in Esmolol treated group compared to Labetalol treated group. Material and methods: Sixty patients of American Society elective surgical procedure, requiring general anaesthesia were divided into 2 groups, Group A patients (30) were given ESMOLOL 1 mg/kg n & Group B (30 patients) were given LABETOLOL 0.25mg/kg. significant difference among mean pulse rate changes from baseline among two groups up to 15 min after study drug. There was significant difference in mean changes in mean arterial pressure and systolic blood pressure from immediat after intubation up to 15 min post intubation. In diastolic blood pressure there was no significant difference in mean changes between two groups at all points of study, except 3 min after intubation which is an isolated finding. There was no significant difference in spo2 between two groups at all points of study.
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