Change in age distribution of COVID-19 deaths with the introduction of COVID-19 vaccination release_63zjuouttfgczccyrmoapk3fbe

by Roberta PASTORINO, Angelo Maria Pezzullo, Leonardo Villani, Francesco Andrea Causio, Cathrine Axfors, Despina Contopoulos-Ioannidis, Stefania Boccia, John Ioannidis

Released as a post by Cold Spring Harbor Laboratory.



Background. Most countries initially deployed COVID-19 vaccines preferentially in elderly populations. Population-level vaccine effectiveness may be heralded by an increase in the proportion of deaths among non-elderly populations that were less covered by vaccination programs. Methods. We collected data from 40 countries on age-stratified COVID-19 deaths during the vaccination period (1/14/2021-5/31/2021) and two control periods (entire pre-vaccination period and excluding the first wave). We meta-analyzed the proportion of deaths in different age groups in vaccination versus control periods in countries with low vaccination rates; (2) countries with age-independent vaccination policies; and (3) countries with standard age-dependent vaccination policies. Findings. Countries that prioritized vaccination among older people saw an increasing share of deaths among 0-69 year old people in the vaccination versus the two control periods (summary prevalence ratio 1.32 [95 CI% 1.24-1.41] and 1.35 [95 CI% 1.26-1.44)]. No such change was seen on average in countries with age-independent vaccination policies (1.05 [95 CI% 0.78-1.41 and 0.97 [95 CI% 0.95- 1.00], respectively) and limited vaccination (0.93 [95 CI% 0.85-1.01] and 0.95 [95 CI% 0.87-1.03], respectively). Prevalence ratios were associated with the difference of vaccination rates in elderly versus non-elderly people. No significant changes occurred in the share of deaths in age 0-49 among all 0-69 deaths in the vaccination versus pre-vaccination periods. Interpretation. The substantial shift in the age distribution of COVID-19 deaths in countries that rapidly implemented vaccination predominantly among elderly may herald the population level-effectiveness of COVID-19 vaccination and a favorable evolution of the pandemic towards endemicity with fewer elderly deaths. Funding. This study received no specific funding.
In application/xml+jats format

Archived Content

There are no accessible files associated with this release. You could check other releases for this work for an accessible version.

Not Preserved
Save Paper Now!

Know of a fulltext copy of on the public web? Submit a URL and we will archive it

Type  post
Stage   unknown
Date   2021-07-23
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 658bcdc8-a73c-4c3a-819f-1eebda059b11