Incidental skin manifestation of trisomy 12 chronic lymphocytic leukemia release_57xybla4vnfjpnpajbicsk6a7q

by Kenneth Rodrigues, Derek Oh, Blerina Asllanaj, Ann Wierman

Published in World Journal of Advanced Research and Reviews by GSC Online Press.

2023   Volume 17, p517-521


Chronic lymphocytic leukemia (CLL) is one of the most prevalent B-cell cancers for people over the age of 65. CLL is commonly comorbid with trisomy 12, as reported in up to 20% of cases. In our case, trisomy 12 was incidentally found on this patient. Its pathophysiology is quite unclear but has played a role in the side effect profile of CLL. Trisomy 12 with CLL has been shown to have increased risk for side effects like thrombocytopenia, Richter transformation and hematological cancers. The goal of this case presentation is to discuss a case of CLL with cutaneous manifestations and to look at the role that trisomy 12 can play.
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Date   2023-02-28
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