Caveolin-1 Regulates Perivascular Aquaporin-4 Expression After Cerebral Ischemia release_53m6vrvdebaurdbuuyk5kki6fm

by Irina Filchenko, Camille Blochet, Lara Buscemi, Melanie Price, Jerome Badaut, Lorenz Hirt

Published in Frontiers in Cell and Developmental Biology by Frontiers Media SA.

Volume 8p371 (2020)


Severe brain edema worsens outcome in stroke patients. Available treatments for stroke-related edema are not efficient and molecular and cellular mechanisms are poorly understood. Cellular water channels, aquaporins (AQPs), are mainly expressed in astrocytes in the brain and play a key role in water movements and cerebral edema, while endothelial caveolins have been suggested to play a role in vasogenic edema. Here we used an integrative approach to study possible interaction between AQP4 and caveolin-1 (Cav-1) after stroke. Absence of Cav-1 was associated with perivascular changes in AQP4 expression and enhanced brain swelling at 3 days after cerebral ischemia. The present work indicates a direct or indirect effect of Cav-1 on perivascular AQP4, which may lead to novel edema therapy.
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Date   2020-05-25
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