Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function release_4dvmpw7pzvetrpk25zzav5jzda

by David C. Glahn, Paul M. Thompson, John Blangero

Published in Human Brain Mapping by Wiley.

2007   Volume 28, Issue 6, p488-501

Abstract

It is vitally important to identify the genetic determinants of complex brain-related disorders such as autism, dementia, mood disorders, and schizophrenia. However, the search for genes predisposing individuals to these illnesses has been hampered by their genetic and phenotypic complexity and by reliance upon phenomenologically based qualitative diagnostic systems. Neuroimaging endophenotypes are quantitative indicators of brain structure or function that index genetic liability for an illness. These indices will significantly improve gene discovery and help us to understand the functional consequences of specific genes at the level of systems neuroscience. Here, we review the feasibility of using neuroanatomic and neuropsychological measures as endophenotypes for brain-related disorders. Specifically, we examine specific indices of brain structure or function that are genetically influenced and associated with neurological and psychiatric illness. In addition, we review genetic approaches that capitalize on the use of quantitative traits, including those derived from brain images.
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Type  article-journal
Stage   published
Year   2007
Language   en ?
DOI  10.1002/hbm.20401
PubMed  17440953
PMC  PMC6871286
Wikidata  Q34620100
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