Numerical workflow of irreversible electroporation for deep-seated tumor release_3ybhhnxzgfaahgdmuixndgqs6m

by Olivier Gallinato, Baudouin Denis de Senneville, Olivier Seror, Clair Poignard

Published in Physics in Medicine and Biology by IOP Publishing.

2019   Volume 64, Issue 5, p055016

Abstract

The paper provides a numerical workflow, based on the 'real-life' clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors. Thanks to a combination of numerical modeling, image registration algorithm and clinical data, our numerical workflow enables to provide the distribution of the electric field as effectively delivered by the clinical IRE procedure. As a proof of concept, we show on a specific clinical case of IRE ablation of liver tumor that clinical data could be advantageously combined to numerical simulations in a near future, in order to give to the interventional radiologists information on the effective IRE ablation. We also corroborate the simulated treated region with the post-treatment MRI performed 3 d after the treatment.
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