{"DOI":"10.21203/rs.3.rs-61570/v1","abstract":"Abstract\n The synaptic tag and capture (STC) hypothesis provides an important theoretical basis for understanding the synaptic basis of associative learning. We recently provided pharmacological evidence that calcium-permeable AMPA receptors (CP-AMPARs) are a crucial component of this process. Here we have investigated two predictions that arise on the basis of CP-AMPARs serving as a trigger of the STC effect. Firstly, we compared the effects of the order in which we delivered a strong theta burst stimulation (TBS) protocol (75 pulses) and a weak TBS protocol (15 pulses) to two independent inputs. We only observed a significant STC effect when the strong preceded the weak TBS. Second, we found that pausing stimulation following either the sTBS or the wTBS for ~20 min largely eliminates the STC effect. These observations are exactly as predicted for a process that is triggered by the synaptic insertion of CP-AMPARs and provide a framework for establishing the underlying molecular mechanism.","author":[{"family":"Park","given":"Pojeong"},{"family":"Kang","given":"Heather"},{"family":"Georgiou","given":"John"},{"family":"Zhuo","given":"Min"},{"family":"Kaang","given":"Bong-Kiun"},{"family":"Collingridge","given":"Graham L"}],"id":"unknown","issued":{"date-parts":[[2020,8,28]]},"publisher":"Research Square","title":"Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses","type":"post"}