Effects of HVP Status on Responsiveness to Ionizing Radiation vs. Photodynamic Therapy in Head and Neck Cancer Cell lines release_3elamxsk5nbenmdqvirn3hqg4i

by David Kessel, Won Jin Cho, Joseph Rakowski, Harold E. Kim, Hyeong‐Reh C. Kim

Abstract

Efficacy of ionizing radiation (I/R) was compared with phototoxic effects of photodynamic therapy (PDT) in vitro using two cell lines derived from patients with head and neck squamous cell carcinoma (HNSCC). A cell line derived from a donor with a human papilloma virus (HPV) infection was more responsive to I/R but significantly less responsive to PDT than a cell line derived from an HPV-free patient. Cell death after I/R in the HPV(+) cell line was associated with increased DEVDase activity, a hallmark of apoptosis. The HPV(-) line was considerably less responsive to I/R, with DEVDase activity greatly reduced, suggesting an impaired apoptotic program. In contrast, the HPV(-) cells were readily killed by PDT when the ER was among the targets for photodamage. While DEVDase activity was enhanced, the death pathway appears to involve paraptosis until the degree of photodamage reached the LD99 range. These data suggest that PDT-induced paraptosis can be a death pathway for cells with an impaired apoptotic program.
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Published in Photochemistry and Photobiology by Wiley
ISSN-L 0031-8655
Release Date 2019-08-13
Publisher Wiley
Primary Language en (lookup)

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Type  article-journal
Stage   published
Date   2019-08-13
DOI  10.1111/php.13150
PubMed  31408910
PMC  PMC7015759
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ISSN-L:  0031-8655
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