by Umasankar Mukhi, Smiatapadma Mohanty

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Rate controlled oral dosage form is the frontier area among novel drug delivery systems. Among all the intragastric drug delivery systems, floating drug delivery systems (FDDS) appears to be one of the most effective and rational approaches for the controlled oral drug deliveries. This FDDS appears to have a distinct advantage in delivering the drugs that are absorbed mainly in the upper part of the GI tract and drugs having stability & solubility problem in the lower part of the intestine. Cefuroxime is a broad spectrum antibiotic. It is a second generation Cephalosporin which is less susceptible to Beta-lactamase. It is absorbed from the gastrointestinal tract. Pro-drug of Cefuroxime is Cefuroxime axetil which is acetoxy ester form. bioavailability of the drug is 30% to 40% when taken on fasting and 5 to 60 % when taken with food. From the above mentioned charcteristesitists of Cefuroxime axetil. It is clear that it (C.A.) had saturated kinetics that could be overcome by slow release of drug from the formulation by incorporation Cefuroxime axetil in controlled release drug delivery system. As Cefuroxime axetil has higher absorption in the proximal region of GI tracts and when a larger amount of Cefuroxime axetil enters to the colon associated with colitis, suggests it is an ideal condition for gastro retentive drug delivery system which will prolong drug release in the GI tract, where absorption of Cefuroxime is good. The present research describes formulation development of an intragastric floating drug delivery system of Cefuroxime axetil using Guar gum with HPMC k4M. All formulations showed acceptable specifications for weight variation, thickness, hardness and friability. The dissolution studies showed release of drug over a period of 12 hours.
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