The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research release_2rmibojafzbi3hck5i2tr3xwoy

by Carol R. Horowitz, Lori A. Orlando, Anne M. Slavotinek, Josh Peterson, Frank Angelo, Barbara Biesecker, Vence L. Bonham, Linda D. Cameron, Stephanie M. Fullerton, Bruce D. Gelb, Katrina A.B. Goddard, Benyam Hailu (+15 others)

Published in American Journal of Human Genetics by Elsevier BV.

2019   Volume 104, Issue 6, p1088-1096

Abstract

Conceptual frameworks are useful in research because they can highlight priority research domains, inform decisions about interventions, identify outcomes and factors to measure, and display how factors might relate to each other to generate and test hypotheses. Discovery, translational, and implementation research are all critical to the overall mission of genomic medicine and prevention, but they have yet to be organized into a unified conceptual framework. To fill this gap, our diverse team collaborated to develop the Genomic Medicine Integrative Research (GMIR) Framework, a simple but comprehensive tool to aid the genomics community in developing research questions, strategies, and measures and in integrating genomic medicine and prevention into clinical practice. Here we present the GMIR Framework and its development, along with examples of its use for research development, demonstrating how we applied it to select and harmonize measures for use across diverse genomic medicine implementation projects. Researchers can utilize the GMIR Framework for their own research, collaborative investigations, and clinical implementation efforts; clinicians can use it to establish and evaluate programs; and all stakeholders can use it to help allocate resources and make sure that the full complexity of etiology is included in research and program design, development, and evaluation.
In text/plain format

Archived Files and Locations

application/pdf  947.7 kB
file_lr5jn4brnjgshmfkiimefyc6ru
europepmc.org (repository)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2019-05-16
Language   en ?
Journal Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  0002-9297
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 59a0939b-b23b-476e-947c-5d44299a3963
API URL: JSON