Survival after Curative Resection for Stage I Colorectal Mucinous Adenocarcinoma release_2dc3kfkp4zhbdhlx64pk2nnbpy

by Liang Huang, Shuangling Luo, Sicong Lai, Yonghua Cai, Zhanzhen Liu, Huanxin Hu, Ziwei Zeng, Cory J Xian, Jianghui Dong, Liping Wang, Liang Kang

Released as a post by Research Square.

2020  

Abstract

<jats:title>Abstract</jats:title> <jats:bold>Background</jats:bold>: The prognostic value of the mucinous adenocarcinoma histotype on the early stages especially for stage I colorectal cancer (CRC) is still unclear. This study determined the clinicopathologic characteristics and long-term outcome of stage I colorectal mucinous adenocarcinomas (MAC). <jats:bold>Methods</jats:bold>: Among the total of 503 patients with stage I CRC (56 having MAC and 447 having non-MAC) who underwent radical resection, the correlation between clinicopathological factors and MAC was analyzed. Multivariate analysis was performed to determine whether mucinous histotype itself was an independent prognostic impact in stage I patients. <jats:bold>Results</jats:bold>: MACs were observed more frequently located in the colon than rectum (<jats:italic>p</jats:italic>=0.046), more frequently displayed the microsatellite instability (MSI) phenotype (<jats:italic>p</jats:italic>=0.023) and had a greater frequency of T2 stage (<jats:italic>p</jats:italic>=0.001). The rate of recurrence was 13.5% and the cancer-specific mortality was 4.3% among all stage I CRC patients. There was no difference in disease-free survival and overall survival between MACs and non-MACs. On multivariate analysis, older age (<jats:italic>p</jats:italic>=0.030,hazard ratio: 2.62), rectal cancer (<jats:italic>p</jats:italic>=0.025, hazard ratio: 5.42), lymphovascular invasion (LVI) (<jats:italic>p</jats:italic>&lt;0.001, hazard ratio: 9.74), and microsatellite stability (MSS) phenotypes (<jats:italic>p</jats:italic>=0.023, hazard ratio: 4.21) were independently associated to poor survival of stage I CRC. A high carcinoembryonic antigen (CEA) level (<jats:italic>p</jats:italic>=0.031, hazard ratio: 1.95), rectal cancer (<jats:italic>p</jats:italic>=0.045, hazard ratio: 1.64), LVI (<jats:italic>p</jats:italic>=0.002, hazard ratio: 3.95) and MSS phenotypes (<jats:italic>p</jats:italic>=0.012, hazard ratio: 2.98) were independently related to short disease-free survival of stage I CRC.<jats:bold>Conclusions</jats:bold>: Compared with non-MAC, MAC patients had more T2 patients and more MSI phenotypes in stage I CRC at presentation, but the mucinous histology is not a significant predictor of recurrence and prognosis in stage I CRC.
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Date   2020-06-22
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