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The Reemergence of Nitrite as a Beneficial Agent in the Treatment of Ischemic Cardiovascular Diseases
release_2aodozyoifa3nn5ixg6dyupj2m
by
Bobby D Nossaman, Haseeb A Akuly, George F Lasker, Vaughn E Nossaman, Philip A Rothberg, Philip J Kadowitz
Published
in Asian journal of experimental biological sciences.
2010 Volume 1, Issue 2, p451-459
Abstract
Nitrite was a therapeutic agent used in the treatment of angina pectoris and hypertension, but was replaced by nitroglycerin. However, nitrite has recently been rediscovered following observations that this anion possesses novel pharmacologic actions such as producing vasodilation, modulating hypoxic vasodilation, and providing cytoprotection in ischemia-reperfusion injury. Moreover, recent observations in animal and human studies have demonstrated that the reduction of nitrite to vasoactive nitric oxide occurs through both enzymatic and non-enzymatic processes. These findings suggest that nitrite may act as a storage form for nitric oxide and provide support for investigating the use of nitrite in the treatment of ischemic disease states including pulmonary hypertension.
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0975-5845
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