Isobornylchalcones as Scaffold for the Synthesis of Diarylpyrazolines with Antioxidant Activity
release_272sowqj4vfqrjtnzlekdekioe
by
Svetlana A. Popova, Evgenia V. Pavlova, Oksana G. Shevchenko, Irina Yu. Chukicheva, Aleksandr V. Kutchin
Abstract
The pyrazoline ring is defined as a "privileged structure" in medicinal chemistry. A variety of pharmacological properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biological properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biologically active molecules. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives.
In application/xml+jats
format
Archived Files and Locations
application/pdf 759.6 kB
file_y4ygf6nemrhlxctd3i7wufdn3i
|
res.mdpi.com (publisher) web.archive.org (webarchive) |
Web Captures
https://www.mdpi.com/1420-3049/26/12/3579/htm
2021-07-11 08:32:20 | 40 resources webcapture_h4yjw6ybsragblyg5dhtvmf7lu
|
web.archive.org (webarchive) |
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registry
ISSN-L:
1420-3049
access all versions, variants, and formats of this works (eg, pre-prints)
Crossref Metadata (via API)
Worldcat
SHERPA/RoMEO (journal policies)
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar