Effect of simulated weightlessness on TNF-alpha production and the response of bone marrow cells to GM-CSF in rats
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[as of editgroup_pfbipmtkjzcr7jzpxvbl7inokq]
by
T Wang, G Yang, P Hu, X Wen
1997 Volume 10, Issue 3, p168-71
Abstract
The purpose of this experiment was to investigate the effect of 15 and 30 d simulated weightlessness (SWL) on tumor necrosis factor-alpha(TNF-alpha) production secreted by macrophage stimulated with lipopolysaccharide(LPS) and the ability of bone marrow cells to respond to granulocyte/monocyte colony-stimulating factor(GM-CSF) in tail-suspension rats. The TNF-alpha production was assessed by radioimmunoassay. The ability of bone marrow cells to respond to GM-CSF was measured by 3H-TdR incorporation method. The results showed that after 15 d SWL, TNF-alpha production showed a tendency to decrease; and that after 30 d SWL, the decrease became significant (P < 0.05). The results also demonstrated that the ability of bone marrow cells to respond to GM-CSF decreased significantly after 15 d SWL (P < 0.01); and there was no significant change after 30 d SWL. It suggested that SWL could depress immune function, and that reduction of TNF-alpha production might be related to bone marrow cell proliferation function.
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