Gestational age reference ranges for umbilical cord blood lactate‐ an external validation study of post‐date pregnancies release_rto3rgpqabbr3c54pzx2cdsebi [as of editgroup_kew2qdidu5bufmobqgru26eiv4]

by Sophie Bowe, Anne C. Staff, Meryam Sugulle

Published in Acta Obstetricia et Gynecologica Scandinavica by Wiley.

2020  

Abstract

A previous study published in 2008 by Wiberg et al. demonstrated increasing umbilical cord blood lactate at delivery by gestational age in vigorous offspring (n=10 169, gestational age 24 to 43 weeks). Based on these results the authors concluded that gestational age independent umbilical cord lactate cut-off could give false-negative or false-positive diagnosis of lacticemia. To our knowledge, these findings have not been incorporated into clinical interpretations in delivery units. In order to perform an external validity study to the findings by Wiberg et al., we analyzed umbilical cord blood lactate levels according to gestational age in a post-date delivery study population at our large, tertiary obstetric unit. The parallel finding of our study to that of Wiberg et al. highlights the importance of using available gestational age dependent reference ranges (eg as presented in Wiberg's publication), when interpreting umbilical cord blood lactate levels for fetal wellbeing.
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Type  article-journal
Stage   published
Date   2020-05-22
Language   en ?
DOI  10.1111/aogs.13922
PubMed  32441769
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ISSN-L:  0001-6349
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