Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis release_y6pnejptl5hs5get7gaqe6s6v4 [as of editgroup_hm7w3nlzzjhrnc7dkywx6qndqu]

by Núria Martínez-Gil, Nerea Ugartondo, Daniel Grinberg, Susanna Balcells

Published in Genes by MDPI AG.

2022   Volume 13, p138

Abstract

The Wnt pathway is involved in several processes essential for bone development and homeostasis. For proper functioning, the Wnt pathway is tightly regulated by numerous extracellular elements that act by both activating and inhibiting the pathway at different moments. This review aims to describe, summarize and update the findings regarding the extracellular modulators of the Wnt pathway, including co-receptors, ligands and inhibitors, in relation to bone homeostasis, with an emphasis on the animal models generated, the diseases associated with each gene and the bone processes in which each member is involved. The precise knowledge of all these elements will help us to identify possible targets that can be used as a therapeutic target for the treatment of bone diseases such as osteoporosis.
In application/xml+jats format

Type  article-journal
Stage   published
Date   2022-01-13
Language   en ?
Container Metadata
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registry
ISSN-L:  2073-4425
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Work In Progress

This entity has not been "accepted" into the official database yet.

Catalog Record
State: wip
Revision: 7441eb73-6d24-486e-a751-df028dde0cf3
API URL: JSON