Chemical Approaches to Analyzing RNA Structure Transcriptome‐Wide release_bcbl77k2qzhmjfeys2uynubq6m [as of editgroup_f76rivyalvemnm2i5lktz55i6i]

by Whitney England, Chely Garfio, Robert Spitale

Published in ChemBioChem by Wiley.

2020  

Abstract

RNA molecules can fold into complex two- and three-dimensional shapes that are critical for their function. Chemical probes have long been utilized to interrogate RNA structure and are now considered invaluable resources in the goal of relating structure to function. Recently, the power of deep sequencing and careful chemical probe design have merged, permitting researchers to obtain a holistic understanding of how RNA structure can be utilized to control RNA biology transcriptome-wide. Within this review, we outline the recent advancements in chemical probe design for interrogating RNA structures inside cells and discuss the recent advances in our understanding of RNA biology through the lens of chemical probing.
In text/plain format

Archived Content

There are no accessible files associated with this release. You could check other releases for this work for an accessible version.

Type  article-journal
Stage   published
Date   2020-07-31
Language   en ?
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  1439-4227
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: d96d6d10-66d2-49e7-94e4-766946f845ed
API URL: JSON