Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats release_jxjjudhcazahvnddi6gsk4fbam [as of editgroup_edyac5a3p5ar5fmbbjhp5unsjm]

by Anna E Sarfaty, Susan R Compton, Peter C Smith, Caroline J Zeiss

Published in Comparative medicine by American Association for Laboratory Animal Science.

2020  

Abstract

Immunodeficient rats are valuable in transplantation studies, but are vulnerable to infection from opportunistic organisms such as fungi. Immunodeficient Rag1- and Il2rg-deficient (RRG) rats housed at our institution presented with dark, proliferative,keratinized dermal growths. Histologic and PCR results indicated that the predominant organism associated with these lesions was fungus from the family Mucoraceae, mostly of the genus Rhizopus. The Mucoraceae family of fungi are environmental saprophytes and are often found in rodent bedding. These fungi can cause invasive opportunistic infectionsin immunosuppressed humans and animals. We discuss husbandry practices for immunosuppressed rodents with a focuson controlling fungal contaminants.
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Type  article-journal
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Date   2020-07-31
Language   en ?
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ISSN-L:  1532-0820
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